There are 32 major airlines in North America, about half of which are from the United States and Canada. A large portion of the flights in North America are operated by budget airlines, the largest 9 being Allegiant Air, Frontier Airlines, JetBlue, Southwest Airlines, Spirit Airlines, Viva Aerobus, Volaris, Flair Airlines and WestJet. In Central America, many flights are operated by Avianca through its subsidiaries Avianca Guatemala, Avianca El Salvador, Avianca Honduras and Avianca Costa Rica. Augusto C. Sandino International Airport is the busiest airport in Nicaragua, although it serves only 1.5 million passengers per year.

Last update: March 2023

– Interjet from Mexico ceased flight operations in December 2020.
– Aeromar from Mexico ceased flight operations in February 2023.
– Swoop (subsidiary WestJet) from Canada ceased flight operations in October 2023.